Kisspeptin-10 (10 mg vial)
Once daily subcutaneous protocol for sexual and cosmetic research.
Kisspeptin sits at the top of the reproductive axis, triggering GnRH release and downstream LH and FSH, and it has genuine human research history in fertility and hypogonadism studies. The protocol below follows the community-standard subcutaneous schedule.
Quick answer: at the standard 10 mg + 1 mL reconstitution, a 200 mcg dose of Kisspeptin-10 draws 2 units (0.02 mL) on a U-100 insulin syringe, once daily subcutaneous.
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Protocol overview
Dosing & reconstitution
Frequency: Once daily subcutaneous
Typical duration: 8-12 weeks
Reconstitution: 10 mg vial + 1 mL bacteriostatic water = 10 mg/mL. Units below are for a U-100 insulin syringe at this concentration.
| Phase | Dose | Units per injection |
|---|---|---|
| Weeks 1-2 | 100 mcg | 1 unit (0.01 mL) |
| Weeks 3-12 | 200 mcg | 2 units (0.02 mL) |
Units = (dose ÷ concentration) × 100 on a U-100 syringe. Change the vial size or water volume and the calculator redoes all of this for you.
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Kisspeptin-10 dosing schedule
From the human physiology research programme, principally at Imperial College London, which has studied kisspeptin in reproductive endocrinology and as a trigger in IVF. These are controlled infusion studies designed to probe the reproductive axis, not a treatment protocol — and administration is intravenous infusion dosed per kilogram per hour, which does not translate to a subcutaneous injection.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Research infusion | Dosed per kg per hour | Continuous intravenous infusion | Kisspeptin-10 has a half-life of minutes, so the research work uses infusion rather than bolus injection. |
| IVF trigger studies | Single bolus, kisspeptin-54 | Subcutaneous, in trial settings | The IVF trigger work largely used kisspeptin-54, a different and longer-acting form than kisspeptin-10. |
Study length: Single infusions or short protocols within research and IVF-trigger settings.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Kisspeptin-10: 10 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 2 mL of bacteriostatic water = 5 mg/mL, so on a U-100 insulin syringe 1 unit = 50 mcg of Kisspeptin-10. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Supplies by protocol length
Based on the maintenance dose above (200 mcg, once daily subcutaneous) and a 10 mg vial reconstituted with 1 mL.
| Duration | Injections | Vials | Syringes | Bac water | Swabs |
|---|---|---|---|---|---|
| 8 weeks | 56 | 2 x 10 mg | 62 | 1 x 10 mL | 112 |
| 12 weeks | 84 | 2 x 10 mg | 93 | 1 x 10 mL | 168 |
| 16 weeks | 112 | 3 x 10 mg | 124 | 1 x 10 mL | 224 |
Syringe count includes ~10% spares. Swabs = 2 per injection (stopper + site). Vial count assumes the full maintenance dose for the entire duration.
Important notes
Practical considerations for consistency and safety.
- Use a new sterile insulin syringe for each injection and dispose in a proper sharps container.
- Inject slowly and steadily; wait a few seconds before withdrawing the needle to ensure complete delivery.
- Administer at the same time each day for consistent levels. Setting a daily reminder helps maintain the schedule.
- The 10 mg vial size is standard for this compound. Reconstitute with 1 mL bacteriostatic water for a convenient concentration.
How Kisspeptin-10 works
The product of the KISS1 gene and the upstream trigger of the reproductive axis: it stimulates GnRH release from the hypothalamus, which drives LH and FSH. It is the master switch that puberty depends on.
Benefits & side effects
Potential benefits
- GnRH stimulator supporting reproductive hormones
- Stimulates LH and FSH release naturally
- Studied in fertility and hypogonadism research
- Supports endogenous hormone production
Possible side effects
- Injection site reactions
- Hot flushes reported
- May affect reproductive hormone levels
- Limited long-term data
This list reflects published literature and community reports. Individual responses vary. Not medical advice.
Bloodwork worth tracking
The community-standard practice is a baseline panel before starting, a recheck 8 to 12 weeks in, and another after time off. For Kisspeptin-10, the markers most worth watching:
LHFSHtestosterone/estradiolCMP
Typical time off: 4-8 wks
Lab panels are how a research protocol stays honest: numbers move before symptoms do. Interpretation belongs with a clinician. Not medical advice.
Lifestyle factors
None of the literature above was run on a background of poor sleep and no protein. These variables move outcomes more reliably than any compound on this site.
- Protein in the 1.6 to 2.2 g/kg range preserves lean mass through any body-composition phase.
- Resistance training 2 to 4 days per week plus 150+ minutes of weekly aerobic work reinforces whatever the protocol is doing.
- Sleep is the recovery window: 7 to 9 hours at consistent times.
- Hydration matters more than usual on compounds with GI or flushing effects: 2 to 3 liters daily.
- Track the variables that matter: weigh-ins, measurements, photos, and labs at sensible intervals.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
References
Quick answers
How many syringe units is a 200 mcg dose of Kisspeptin-10?
At the standard reconstitution of 10 mg with 1 mL bacteriostatic water (10 mg/mL), a 200 mcg dose draws 2 units (0.02 mL) on a U-100 insulin syringe.
How do you reconstitute Kisspeptin-10?
Add 1 mL of bacteriostatic water to the 10 mg vial for 10 mg/mL. Inject the water slowly down the inside wall of the vial, swirl gently without shaking, and refrigerate at 2 to 8 °C after mixing.
How long does a 10 mg vial of Kisspeptin-10 last?
About 50 maintenance doses of 200 mcg, roughly 7.1 weeks at once daily subcutaneous.
Does Kisspeptin-10 have human trial data?
Yes. The dosing on this page is anchored to published human research (Dhillo WS and colleagues, kisspeptin human reproductive physiology and IVF trigger studies).
How does Kisspeptin-10 work?
The product of the KISS1 gene and the upstream trigger of the reproductive axis: it stimulates GnRH release from the hypothalamus, which drives LH and FSH. It is the master switch that puberty depends on.
Sourcing Kisspeptin-10
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Kisspeptin-10 at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
