Melanotan II (10 mg vial)
Once daily loading, then 1-2x weekly maintenance protocol for sexual and cosmetic research.
Melanotan II is a non-selective melanocortin agonist, which is why tanning arrives alongside libido and appetite effects: it hits several receptors at once. It remains a research chemical with no approved form. The protocol below is a low-dose loading phase then one or two maintenance doses weekly.
Quick answer: at the standard 10 mg + 1 mL reconstitution, a 500-1000 mcg 1-2x/wk dose of Melanotan II draws 5-10 units (0.05-0.1 mL) on a U-100 insulin syringe, once daily loading, then 1-2x weekly maintenance.
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Protocol overview
Dosing & reconstitution
Frequency: Once daily loading, then 1-2x weekly maintenance
Typical duration: 8-16 weeks
Reconstitution: 10 mg vial + 1 mL bacteriostatic water = 10 mg/mL. Units below are for a U-100 insulin syringe at this concentration.
| Phase | Dose | Units per injection |
|---|---|---|
| Week 1 | 250 mcg | 2.5 units (0.025 mL) |
| Week 2 | 500 mcg | 5 units (0.05 mL) |
| Week 3 | 750 mcg | 7.5 units (0.075 mL) |
| Weeks 4-8 | 1 mg | 10 units (0.1 mL) |
| Maintenance | 500-1000 mcg 1-2x/wk | 5-10 units (0.05-0.1 mL) |
Units = (dose ÷ concentration) × 100 on a U-100 syringe. Change the vial size or water volume and the calculator redoes all of this for you.
Track this protocol → Free account · log doses, rotate sites, never lose your history
Melanotan II dosing — what the literature actually supports
We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Melanotan II: 10 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 2 mL of bacteriostatic water = 5 mg/mL, so on a U-100 insulin syringe 1 unit = 50 mcg of Melanotan II. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Supplies by protocol length
Based on the maintenance dose above (500-1000 mcg 1-2x/wk, once daily loading, then 1-2x weekly maintenance) and a 10 mg vial reconstituted with 1 mL.
| Duration | Injections | Vials | Syringes | Bac water | Swabs |
|---|---|---|---|---|---|
| 8 weeks | 56 | 6 x 10 mg | 62 | 1 x 10 mL | 112 |
| 12 weeks | 84 | 9 x 10 mg | 93 | 1 x 10 mL | 168 |
| 16 weeks | 112 | 12 x 10 mg | 124 | 2 x 10 mL | 224 |
Syringe count includes ~10% spares. Swabs = 2 per injection (stopper + site). Vial count assumes the full maintenance dose for the entire duration.
Important notes
Practical considerations for consistency and safety.
- Use a new sterile insulin syringe for each injection and dispose in a proper sharps container.
- Rotate injection sites (abdomen, thighs, upper arms) systematically to reduce local irritation and avoid lipohypertrophy.
- Inject slowly and steadily; wait a few seconds before withdrawing the needle to ensure complete delivery.
- Administer on the same day each week for consistency. If a dose is missed, administer as soon as possible within a few days.
- Administer at the same time each day for consistent levels. Setting a daily reminder helps maintain the schedule.
- This compound lacks controlled human safety data. Start with the lowest reported amount and increase gradually while monitoring for any adverse reactions.
- The 10 mg vial size is standard for this compound. Reconstitute with 1 mL bacteriostatic water for a convenient concentration.
How Melanotan II works
A cyclic, non-selective melanocortin agonist. Unlike Melanotan I it hits MC1, MC3, MC4 and MC5 — the MC4 activity is why it produces sexual and appetite effects alongside pigmentation, and PT-141 is a metabolite of it.
Benefits & side effects
Potential benefits
- Non-selective melanocortin agonist
- Stimulates tanning, libido and appetite suppression
- Loading then maintenance dosing
- Multiple effects from broad receptor activity
Possible side effects
- Nausea common during loading
- Facial flushing
- Spontaneous erections
- Must monitor moles and skin changes (non-selective)
This list reflects published literature and community reports. Individual responses vary. Not medical advice.
Bloodwork worth tracking
The community-standard practice is a baseline panel before starting, a recheck 8 to 12 weeks in, and another after time off. For Melanotan II, the markers most worth watching:
CMPCBCblood pressuredermatology check
Typical time off: Maintenance 1-2x/wk once desired
Lab panels are how a research protocol stays honest: numbers move before symptoms do. Interpretation belongs with a clinician. Not medical advice.
Lifestyle factors
None of the literature above was run on a background of poor sleep and no protein. These variables move outcomes more reliably than any compound on this site.
- Protein in the 1.6 to 2.2 g/kg range preserves lean mass through any body-composition phase.
- Resistance training 2 to 4 days per week plus 150+ minutes of weekly aerobic work reinforces whatever the protocol is doing.
- Sleep is the recovery window: 7 to 9 hours at consistent times.
- Hydration matters more than usual on compounds with GI or flushing effects: 2 to 3 liters daily.
- Track the variables that matter: weigh-ins, measurements, photos, and labs at sensible intervals.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Quick answers
How many syringe units is a 500-1000 mcg 1-2x/wk dose of Melanotan II?
At the standard reconstitution of 10 mg with 1 mL bacteriostatic water (10 mg/mL), a 500-1000 mcg 1-2x/wk dose draws 5-10 units (0.05-0.1 mL) on a U-100 insulin syringe.
How do you reconstitute Melanotan II?
Add 1 mL of bacteriostatic water to the 10 mg vial for 10 mg/mL. Inject the water slowly down the inside wall of the vial, swirl gently without shaking, and refrigerate at 2 to 8 °C after mixing.
How long does a 10 mg vial of Melanotan II last?
About 10 maintenance doses of 500-1000 mcg 1-2x/wk, roughly 1.4 weeks at once daily loading, then 1-2x weekly maintenance.
Does Melanotan II have human trial data?
No. The evidence base is animal and cell studies; the practical dosing shown is community convention, and the page labels it that way.
How does Melanotan II work?
A cyclic, non-selective melanocortin agonist. Unlike Melanotan I it hits MC1, MC3, MC4 and MC5 — the MC4 activity is why it produces sexual and appetite effects alongside pigmentation, and PT-141 is a metabolite of it.
Sourcing Melanotan II
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Melanotan II at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
